期刊 健择联合顺铂治疗晚期非小细胞肺癌的临床观察  被引量:3

Gemcitabine combined with cisplatin in treatment of advanced non-small cell lung cancer

作  者:李益荣 路云青 

机构地区:[1]山东省滨州市结防院

出  处:《临床肺科杂志》2006年第4期476-477,共2页Journal of Clinical Pulmonary Medicine

Gemcitabine combined with cisplatin in treatment of advanced non-small cell lung cancer

摘  要:目的 观察健择(GEM)加顺铂(DDP)联合治疗晚期非小细胞肺癌,临床疗效及毒副反应。方法 健择1000mg/m。静滴30min第1、8天。顺铂40mg静滴,第1、2、3天。每21~28天为1周期,2周期后评价疗效及毒副反应。结果 临床疗效:50例患者均接受2个周期化疗。其中CR:0例,PR:24例,NC:19例,PD:7例,总有效率为48%,其中Ⅲb期有效率为53-8%(15/28),Ⅳ期有效率为40.9%(9/22)。结论 健择加顺铂联合治疗晚期非小细胞肺癌疗效确切,副作用较少,是一种值得推荐的化疗方案。

Objective To observe the clinical effects of using gemcitabine (GEM) combined with cisplatin (DDP) in treating advanced non-small cell lung cancer and its side effects. Methods Gemcitabine 1000 mg/m^2 was dripped for 30 minutes at the 1 st and at the 8th days. Cisplatin 40 mg was dripped athe l st, 2nd and 3rd days of the chemotherapy. Every 21 to 28 days represented a treatment cycle. After two cycles of the chemotherapy, the curative effects and adverse reactions were evaluated. Results All 50 patients were through 2 cycles of the chemotherapy. There was no case of CR, and there were 24 cases of PR, 19 cases of NC, 7 cases of PD with an overall effective rate being 48. 0%. The overall response rates were 53.8% (15/28) in Stage Ⅲb and 40.9% (9/22) in Stage Ⅳ patients. Conclusion Gemcitabine combined with cisplatin as the chemotherapy is very effective in treating advanced non-small cell lung cancer. It has few adverse reaction. It is a recommended regimen for treatment of advanced non-small cell lung cancer patients.

关 键 词:非小细胞肺癌 健择 顺铂 化疗 

non-small cell lung cancer  gemcitabine  eisplatin  chemothearpy 

分 类 号:R734.2[医药卫生—肿瘤] R711.32[医药卫生—临床医学]

 

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