期刊 甲状旁腺激素相关肽与糖尿病性骨质疏松性骨折:你知道哪些?  被引量:3

Parathyroid hormone related peptides affect diabetic osteoporotic fracture

作  者:刘岸龙 邱勇[2] 王银河[2] 

机构地区:[1]南京中医药大学中西结合鼓楼临床医学院 [2]南京市鼓楼医院

出  处:《中国组织工程研究》2014年第15期2442-2449,共8页Chinese Journal of Tissue Engineering Research

Parathyroid hormone related peptides affect diabetic osteoporotic fracture

基  金:国家自然科学基金(81271997);南京市卫生局重点课题(ZKX10007);中国博士后基金(20100481130);江苏省"科教兴卫"医学重点人才(RC2011150)~~

摘  要:背景:甲状旁腺激素相关肽是在伴有高钙血症的癌症患者中被发现的一种多肽类物质,作为一种潜在的促进骨折愈合的药物,具有重要的临床应用价值。目的:探讨甲状旁腺激素相关肽在糖尿病性骨质疏松骨折中的调控作用。方法:计算机检索医脉通中文文献数据库以及PubMed 1990至2013年期间有关甲状旁腺激素相关肽的文章。检索词分别为"甲状旁腺激素相关肽,糖尿病,骨质疏松性骨折"和"Parathyroid hormone related peptides,diabetes,osteoporotic fracture"。初检得到1 279篇文献,最终纳入文章43篇进入结果分析。结果与结论:动物实验和临床研究表明:甲状旁腺激素相关肽对于骨折愈合有明显的促进作用,同时对于糖尿病相关的胰岛细胞功能缺陷有良好的修复作用;其类似物甲状旁腺激素已作为治疗骨折的临床用药。但是甲状旁腺激素相关肽的临床用药剂量,骨折愈合不同分期的具体使用方法包括联合用药还有待进一步研究。

BACKGROUND:Parathyroid hormone related peptides are accompanied by the syndrome of humoral hypercalcemia of malignancy. As a potential therapeutic drug of promoting the healing of bone fracture, parathyroid hormone related peptides have significant clinical application value. OBJECTIVE:To explore the regulating effects of parathyroid hormone related peptides in diabetic osteoporotic fracture METHODS:A computer-based online research of CNKI and PubMed databases was performed to col ect articles published between 1990 and 2013, with the key words“parathyroid hormone related peptides, diabetes, osteoporotic fracture”in Chinese and English. There were 1 279 articles after the initial survey. A total of 43 articles were included according inclusion and exclusion criteria. RESULTS AND CONCLUSION:Animal and clinical experiments demonstrated that parathyroid hormone related peptides notably accelerate bone fracture healing, and improve the repair process of islet cellfunction defects that are related with diabetes. Meanwhile, as an analogue, parathyroid hormone has been identified as clinical medication in the treatment of fracture. But the appropriate dose, and method of application at the different stages of bone fracture healing and the problem of drug combination need further investigation.

关 键 词:组织构建 骨组织工程 甲状旁腺激素相关肽 糖尿病 骨质疏松 骨折 国家自然科学基金 

parathyroid hormone  diabetes mellitus  osteoporosis  osteoporotic fractures 

分 类 号:R318[医药卫生—生物医学工程]

 

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