期刊 丁苯酞对急性缺血性脑卒中患者循环内皮祖细胞水平的影响  被引量:6

Influence of Butylphthalide on Circulating Endothelial Progenitor Cells in Patients with Acute Ischemia Stroke

作  者:熊军 胡增 

机构地区:[1]湖北省武汉市普仁医院

出  处:《中国药业》2016年第10期29-31,共3页China Pharmaceuticals

Influence of Butylphthalide on Circulating Endothelial Progenitor Cells in Patients with Acute Ischemia Stroke

摘  要:目的观察丁苯酞对急性缺血性脑卒中患者循环内皮祖细胞水平的影响。方法选取首次发作48 h内的急性缺血性脑卒中患者96例,按就诊时间随机分为对照组和观察组,各48例。对照组患者静脉滴注银杏叶提取物注射液(20 m L/d)、口服阿司匹林肠溶片(100 mg/d)治疗,观察组患者在对照组治疗基础上给予丁苯酞软胶囊(200 mg,每日1次)口服治疗。两组患者均以4周为1个疗程,治疗3个疗程。记录两组患者治疗前后美国国立卫生院脑卒中量表评分(NIHSS),以评价临床疗效,检测外周血内皮祖细胞(EPCs)数量及迁移能力、血脂水平,定期检查血常规、肝肾功能,并记录治疗过程中不良反应的发生情况。结果观察组总有效率为89.58%,显著高于对照组的75.00%(P<0.05);治疗后,观察组患者外周血EPCs数量及迁移能力均明显高于对照组(P<0.05);观察组血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平较对照组均明显降低(P<0.05),高密度脂蛋白胆固醇(HDL-C)较对照组明显增高(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论加用丁苯酞治疗急性缺血性脑卒中的临床疗效好,能有效改善患者的神经功能损伤,增加EPCs数量,增强其向损伤区域的迁移能力,帮助调节血脂,不良反应少,值得临床推广。

Objective To observe the effect of butylphthalide on circulating endothelial progenitor cells in patients with acute ischemia stroke. Methods 96 patients in the hospital diagnosed as acute ischemia stroke in 48 h were randomly divided into the treatment group and the control group,48 cases in each group. The control group was treated with extract of Ginkgo Biloba Injection( 20 m L / d)and aspirin enteric tablets( 100 mg / d); on this basis,the treatment group was added with butylphthalide( 200 mg,qd). 4 weeks was 1course of treatment,and the medication lasted for 3 courses. The NIHSS scores in each group were detected and recorded for the clinical efficacy,the amounts and the transfer ability of EPCs in peripheral blood were detected by flow cytometry,the TC,TG,LDL- C,HDL- C level in peripheral blood were observed,and the adverse reactions during treatment were recorded. Results The total effective rate of the treatment group was 89. 58%,which was significantly higher than 75. 00% of the control group( P〈0. 05); After treatment the amounts and the transfer ability of EPCs in peripheral blood in the treatment group were significantly better than the control group( P〈0. 05); the levels of TC,TG and LDL- C in the treatment group were decreased compared with the control group( P〈0. 05),and the level of HDL- C was significantly increased compared with the control group( P〈0. 05). The incidence rate of adverse reactions in the two groups groups had no significant difference( P〈0. 05). Conclusion Butylphthalide can improve the nerve function deficit in patients with acute ischemia stroke effectively,increase the amounts of EPCs,improve the transfer ability of EPCs,inhibit the brain microcirculation thrombosis,with distinct clinical efficacy and fewer adverse reactions,which is worthy of clinical promotion.

关 键 词:丁苯酞 急性缺血性脑卒中 内皮祖细胞 临床疗效 

butylphthalide  acute ischemia stroke  endothelial progenitor cells  clinical efficacy 

分 类 号:R969.4[医药卫生—药理学] R972[医药卫生—药学]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关文献:

正在载入数据...

北京电子科技职业学院特色库 版权所有 ©2018