期刊 舌下微循环成像系统在心肌梗死后远端微循环变化观察中的应用  被引量:1

Application of hypoglossal microcirculation imaging system in observation of distal microcirculation after myocardial infarction

作  者:冯健 朱忠立 李运明 向朝雪 唐名扬 沈阳 魏晓禹 裴海峰 

FENG Jian;ZHU Zhong-li;LI Yun-ming;XIANG Chao-xue;TANG Ming-yang;SHEN Yang;WEI Xiao-yu;PEI Hai-feng(Department of Cardiovascular Medicine,General Hospital of Western Theater Command,Chengdu 610083,China;Department of Critical Care Medicine,General Hospital of Western Theater Command,Chengdu 610083,China;Department of Information,General Hospital of Western Theater Command,Chengdu 610083,China)

机构地区:[1]西部战区总医院心血管内科 [2]西部战区总医院重症医学科 [3]西部战区总医院信息科

出  处:《解放军医学杂志》2019年第4期276-280,共5页Medical Journal of Chinese People's Liberation Army

Application of hypoglossal microcirculation imaging system in observation of distal microcirculation after myocardial infarction

基  金:国家自然科学基金(81500208);中国博士后基金(2017M613429);四川省杰出青年基金(2017JQ0012)~~

摘  要:目的探索舌下微循环成像系统(简称微视系统)应用于心脏微血管检测的可行性,并探讨其在冠脉微循环障碍诊断、治疗及预后评估中的临床价值。方法以正常SD大鼠作为研究对象,利用微视系统对大鼠冠脉主干及其分支微循环进行检测。另取40只SD大鼠随机分为心肌梗死组(n=20)与假手术组(n=20),心肌梗死组大鼠结扎左冠状动脉前降支制作心肌梗死模型,假手术组与心肌梗死组接受同样处理但不结扎。利用微视系统对假手术组及心肌梗死组大鼠手术前及手术后5、10、20min左前降支远端微血管进行检测和分析,检测指标包括总血管密度(TVD)、灌注血管密度(PVD)、灌注血管比例(PPV)、微血管流动指数(MFI)、异质性指数(HI)。结果微视系统下,正常大鼠心脏左右冠脉及其分支微血管清晰可见,血流灌注连续,血管密集、分布均匀。在心肌梗死组大鼠中,结扎时间越长,微血管脉络越模糊不清,血流显影中断,血管分布不均,心肌梗死20min时点微循环基本不显像,血流基本消失。与心肌梗死5min时点比较,心肌梗死10、20min的TVD、PVD、PPV、MFI均降低(P<0.05),HI升高(P<0.05)。与假手术组比较,心肌梗死组TVD、PVD、PPV、MFI均降低(P<0.05),HI升高(P<0.05)。结论微视系统可用于正常及病变状态下大鼠心脏微循环的检测。

Objective To explore the feasibility of detecting cardiac microvessel with hypoglossal microcirculatory imaging system(abbreviated as microvision system),and explore its clinical value in diagnosis,treatment and prognosis evaluation of coronary microcirculation disorder.Methods Normal SD rats were used as research objects to detect the microcirculation of the main coronary artery and its branches with microvision system.Forty SD rats were randomly divided into two groups(20 each):myocardial infarction(MI)group and sham operation(Sham)group.The left anterior descending branch of coronary artery was ligated to make the model of myocardial infarction in MI group,and the sham group received the same treatment as in MI group but no ligation.The microvessel of left anterior descending branch was detected and analyzed in sham group and MI group before operation and 5,10 and 20 minutes after operation by microvision system.The measured parameters included the total vessel density(TVD),the perfused vessel density(PVD),the proportion of perfused vessels(PPV),the microcirculatory flow index(MFI)and the heterogeneity index(HI).Results In microvision system,the left and right coronary vessels and their branches in the normal rat heart were clearly visible,the blood flow perfusion was continuous,and the blood vessels were dense and evenly distributed.In MI group,the longer the ligation time,the more blurred the vein of the microvessel.Furthermore,the blood flow was interrupted and the vessels were non-uniform distribution.The microcirculation was invisible and blood flow disappeared at 20min time point after infarction.Compared with that at 5min time point,TVD,PVD,PPV and MFI decreased,while HI increased at 10min and 20min time points(P<0.05).Compared with that in sham group,TVD,PVD,PPV and MFI decreased,while HI increased in MI group(P<0.05).Conclusion The microvision system can be used to detect cardiac microcirculation in normal and pathological conditions of rats.

关 键 词:心肌梗死 心脏微循环 舌下微循环成像系统 大鼠 

myocardial infarction cardiac microcirculation hypoglossal microcirculation imaging system rat 

分 类 号:R331[医药卫生—人体生理学]

 

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