期刊 促皮质素联合维生素B6对痉挛症患儿星形胶质细胞分子标志物S-100β及胶质纤维酸性蛋白表达影响  被引量:1

Effect of corticotropin combined with vitamin B6 on astrocyte molecular markers S-100β and glial fibrillary acidic protein expression in children with snoring

作  者:戴刚 

Dai Gang(Department of Paediatrics, Maternal and Child Health Care Hospital of Longquanyi District, Chengdu, Sichuan, 610100, China)

机构地区:[1]成都市龙泉驿区妇幼保健院儿科

出  处:《当代医学》2019年第26期48-50,共3页Contemporary Medicine

Effect of corticotropin combined with vitamin B6 on astrocyte molecular markers S-100β and glial fibrillary acidic protein expression in children with snoring

摘  要:目的探讨促皮质素联合维生素B6对痉挛症(IS)患儿星形胶质细胞分子标志物S-100β及胶质纤维酸性蛋白表达的影响。方法选取2012年10月至2017年10月期间在本院确诊的60例痉挛症患儿,随机分为观察组和对照组,观察组给予维生素B6联合促皮质素(ACTH)治疗,对照组给予维生素B6联合左乙拉西坦治疗。观察两组患儿治疗后病情改善情况、脑电图、血常规、肝肾功能、血电解质等变化及预后情况,并采用ELISA法检测两组治疗前后血清S-100β及胶质纤维酸性蛋白(GFAP)表达情况。结果治疗后观察组血清S-100β、GFAP水平(0.47±0.15、2.01±0.32)显著低于对照组(0.69±0.12、3.37±0.41),差异有统计学意义(P<0.05);观察组患儿治疗后痉挛完全控制率、有效率(60.0%、96.7%)显著高于对照组(46.7%、76.7%),差异有统计学意义(P<0.05);治疗1个月、治疗2个月后观察组患儿脑电图完全控制率(75.40±8.21、72.16±6.40)显著高于同期对照组(60.42±5.35、52.25±5.26),差异有统计学意义(P<0.05);两组患儿治疗后血象、肝肾功能及血电解质均无严重异常反应;随访期间观察组复发率6.67%显著高于对照组复发率33.3%,差异有统计学意义(P<0.05)。结论促皮质素联合维生素B6能够降低痉挛症患儿星形胶质细胞分子标志物S-100β及胶质纤维酸性蛋白表达,有效改善痉挛症状,安全性高,预后好,值得临床大力推广。

Objective To investigate the effect of corticotropin combined with vitamin B6 on the expression of astrocyte molecular markers S-100β and glial fibrillary acidic protein in children with snoring(IS). Methods Sixty children with hysteria diagnosed in our hospital from October2012 to October 2017 were randomly divided into observation group and control group. The observation group was given vitamin B6 combined with corticotropin(ACTH) treatment, and the control group was given vitamins B6 combined with levetiracetam treatment. Were observed in children after treatment to improve the condition and prognosis situation changes, EEG, blood, liver and kidney function, blood electrolytes, and S-100β and levels of serum glial fibrillary acidic protein before and after treatment were detected by ELISA(GFAP) expression were observed between two groups of children. Results The levels of serum S-100β and GFAP in the observation group(0.47±0.15, 2.01±0.32) were significantly lower than those in the control group(0.69±0.12, 3.37±0.41), and the difference was statistically significant(P<0.05). After treatment, the complete control rate and effective rate(60.0%, 96.7%) were significantly higher than the control group(46.7%, 76.7%), the difference was statistically significant(P<0.05);1 month after treatment, 2 months after treatment The complete control rate of EEG in the observation group(75.40±8.21, 72.16±6.40) was significantly higher than that of the control group(60.42±5.35, 52.25±5.26), the difference was statistically significant(P<0.05);There was no serious abnormal reaction in blood, liver and kidney function and blood electrolyte after treatment. During the follow-up period, the recurrence rate of the observation group was 6.67% significantly higher than that of the control group 33.3%, and the difference was statistically significant(P<0.05). Conclusion Corticotropin combined with vitamin B6 can reduce the expression of astrocyte molecular markers S-100β and glial fibrillary acidic protein in children with

关 键 词:促皮质素 维生素B6 痉挛症患儿 星形胶质细胞分子标志物 胶质纤维酸性蛋白 

Corticotropin Vitamin B6 Children with snoring Astrocyte molecular markers Glial fibrillary acidic protein 

分 类 号:R743.31[医药卫生—神经病学与精神病学]

 

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