期刊 丹红注射液对下肢骨折术后患者凝血和炎症的影响  

Influence of Danhong Injection on Blood Coagulation and Inflammationin Patients with Lower Extremity Fractures after Operation

作  者:陈琼[1] 

CHEN Qiong(Department of Pharmacy,Zhengzhou Orthopedichospital,Zhengzhou 450052,China)

机构地区:[1]郑州市骨科医院药学部,郑州450052

出  处:《中国合理用药探索》2020年第3期69-73,共5页Chinese Journal of Rational Drug Use

Influence of Danhong Injection on Blood Coagulation and Inflammationin Patients with Lower Extremity Fractures after Operation

摘  要:目的:探讨丹红注射液对下肢骨折术后患者凝血和炎症的影响。方法:选取2017年5月~2019年10月本院收治的113例拟行手术内固定治疗的下肢骨折患者,随机分为对照组(56例)和研究组(57例)。对照组术后予以常规处理;研究组在常规处理基础上给予丹红注射液静脉滴注。对比治疗前、治疗1周后、治疗2周后的凝血相关指标[凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血酶原时间(APTT)、纤维蛋白原(FIB)]及炎症因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-4(IL-4)、白介素-6(IL-6)]水平变化情况,以及局部(骨折部位)疼痛明显缓解时间、肿胀消退时间。分析两组用药安全性。结果:PT、TT、APTT、FIB、CRP、TNF-α、IL-4、IL-6在组间、时间、交互方面有统计学差异(P<0.05)。两组的PT、TT、APTT、IL-4均为治疗2周后>治疗1周后>治疗前,FIB、CRP、TNF-α、IL-6水平均为治疗2周后<治疗1周后<治疗前,有统计学差异(P<0.05)。研究组治疗1周、2周后的PT、TT、APTT均长于治疗前和对照组,FIB水平低于治疗前和对照组,IL-4水平高于治疗前和对照组,CRP、TNF-α、IL-6水平低于治疗前和对照组,有统计学差异(P<0.05)。研究组局部疼痛明显缓解时间、肿胀消退时间均短于对照组,有统计学差异(P<0.05)。两组的不良反应发生率无统计学差异(P>0.05),且患者均可耐受。结论:在下肢骨折术后应用丹红注射液,可明显改善患者机体凝血状态,减轻炎症反应,缓解疼痛及消退肿胀,且安全。

Objective: To explore the influence of Danhong Injection on blood coagulation and inflammation in patients with lower extremity fractures after operation. Methods: From May 2017 to October 2019,113 patients with lower extremity fractures treated with internal fixation were randomly divided into two groups,the control group( 56 cases) and the test group( 57 cases). Routine treatment was given in the control group after operation,while the test group was additionally given intravenous Danhong injection on that basis. The coagulation related indexes [prothrombin time( PT),thrombin time( TT),activated partial prothrombin time( APTT) and fibrinogen( FIB) ] and inflammatory factors [C-reactive protein( CRP),tumor necrosis factor-α( TNF-α),interleukin-4( IL-4) and interleukin-6( IL-6) ] were compared before treatment,1 week and 2 weeks after treatment. The time of pain relief and local swelling( fracture site),as well as drug safety were compared between two groups. Results: There were significant differences in PT,TT,APTT,FIB,TNF-α,IL-4,IL-6 among groups,time points and interactions( P< 0.05). The results of PT,TT,APTT and IL-4 in both groups were found significantly increased over time( P < 0.05). While the levels of FIB,CRP,TNF-α and IL-6 in the two groups decreased over time( P< 0.05). The PT,TT and APTT in the test group were elevated after treatment and also higher than those in the control group after 1 and 2 weeks of treatment. IL-4 was relatively higher in the test group comparing with that collected before treatment or in the control group. The levels of FIB,CRP,TNF-α and IL-6 were lower in the test group than those in the control group( P< 0.05). The time of local pain relief and swelling abatement in the test group were shorter than that in the control group( P < 0. 05). There was no significant difference in the incidence of adverse reactions between the groups( P > 0. 05). Patients showed no obvious intolerance. Conclusion: The application of Danhong injection after the operation in patients with lowe

关 键 词:丹红注射液 下肢骨折 手术 凝血功能 炎症因子 

Danhong injection lower extremity fractures operation coagulation function inflammatory factors 

分 类 号:R973[医药卫生—药品]

 

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