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期刊Taxotere resistance in SUIT Taxotere resistance in pancreatic carcinoma cell line SUIT 2 and its sublines被引量:2
《世界胃肠病学杂志:英文版》2001年第6期855-859,共5页Edgar Staren Takeshi lwamura HubertAppert JohnHoward 
Supported in part by Phne-Poulenc Rorer Pharmaceuticals INC.
AIM: To investigate the specific mechanisms of intrinsic and acquired resistance to taxotere (TXT) in pancreatic adenocarcinoma (PAC). METHODS: MTT assay was used to detect the sensitivity of PAC cell line SUIT-2 and...显示全部
关键词:pancreatic neoplasms/pathology tumor cells  cultured/drug effects paclitaxel/analogs & derivatives paclitxael/pharmacology drug resistance multiple drug resistance  neoplasm 
期刊Effects of aminoguanidine on nitric oxide production induced by inflammatory cytokines and endotoxin in cultured rat hepatocytes
《世界胃肠病学杂志:英文版》2001年第3期331-334,共4页Guo Liang Zhang Ye Hong Wang Hui Ling Teng Zhi Bin Lin Department of Pharmacology,School of Basic Medical Sciences,Beijing University,Beijiog 100083,ChinaDr.Guo Liang Zhang graduated from Xinxiang Medical College in 1982,got Ph.D.at Nagoya City University Medical School,Japan in 1994,finished postdoctoral research at Beijing Medical Univcrsity in 1996,now an associate professor of pharmacology,specialized in hepatic pharmacology,having 15 papers published. 
Project supported by the National Natural Science Foundation of China,No.39770861.and JANSSEN Science Research Foundation.
AIM To study the effects of aminoguanidine(AG) and two L-arginine analogues Nω-nitro-L-arginine methyl ester (L-NAME) and Nω-nitro-L-arginine (L-NNA) on nitric oxide (NO) productioninduced by cytokines (TNF-α, IL-1...显示全部
关键词:NITRIC-OXIDE synthase/antagonists & inhibitors nitric oxide/biosynthesis liver/cytology cells  cultured/drug EFFECTS endotoxins/pharmacology IMMUNOLOGIC and biological factors/pharmacology 
期刊Antihepatoma effect of alpha-fetoprotein antisense phosphorothioate oligodeoxyribonucleotides in vitro and in mice被引量:5
《世界胃肠病学杂志:英文版》2001年第3期345-351,共7页Xing Wang Wang~1 Jin Hui Yuan~1 Ru Gang Zhang~1 Li Xia Guo~1 Yong Xie~2 Hong Xie~1 ~1Department of Biotherapy,Shanghai Institute of Cell Biology,Chinese Academy of Sciences,Shanghai 200031,China ~2Department of Biology,Hong Kong University of Science and Technology,ChinaDr.Xing Wang Wang earned Ph.D.from Shanghai Institute of Materia Medical,Chinese Academy of Sciences in 1997.Now a professor at Shanghai Institute of Cell Biology,Chinese Academy of Sciences. 
Supported by the National Postdoctoral Science Foundation of China,No.199711.
AIM To evaluate antihepatoma effect ofantisense phosphorothioate oligodeo-xyribonucleotides (S-ODNs) targeted to alpha-fetoprotein (AFP) genes in vitro and in nudemice.METHODS AFP gene expression was examinedby immuno...显示全部
关键词:alpha-fetoproteins/genetics oligodeoxyribonucleotides  antisense/pharmacology liver neoplasms/pathology tumor cells  cultured/drug EFFECTS gene expression/drug EFFECTS 
期刊Experimental study on antitumor effect of arsenic trioxide in combination with cisplatin or doxorubicin on hepatocellular carcinoma被引量:10
《世界胃肠病学杂志:英文版》2001年第5期702-705,共4页Wei Wang~1 Shu-Kui Qin~1 Bao-An Chen~2 Hui-Ying Chen~1 1 Chinese PLA Cancer Center,Chinese PLA 81 Hospital,Nanjing 210002,Jiangshu Province,China2 Affliliated Zhongda Hospital of Southeast University Medical College,Nanjing 210087,Jiangsu Province,China 
Supported by the Youth Science Grant of Jiangshu Province,No.BQ98048.
INTRODUCTION The main component of a traditional Chinese drug 'Pishuang'. arsenic trioxide (As2O3), has obviously selective anti-tumor effect on human hepatocellular carcinoma (HCC)in both in vitro and in vivo...显示全部
关键词:liver neoplasms carcinoma hepatocellular MINOR cells  cultured/drug effects arsenicals/pharmacology cisplatin/pharmacology doxorubicin/pharmacology 
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