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期刊Synchrotron-Infrared Microscopy Analysis of Amyloid fibrils Irradiated by Mid-Infrared Free-Electron Laser
《美国分析化学(英文)》2014年第6期384-394,共11页Takayasu Kawasaki Toyonari Yaji Takayuki Imai Toshiaki Ohta Koichi Tsukiyama 
Amyloid fibrils are widely recognized as a cause of serious amyloidosis such as Alzheimer’s disease. Although dissociation of amyloid fibril aggregates is expected to lead to a decrease in the toxicity of the fibrils...显示全部
关键词:AMYLOID fibrils Free-Electron Laser Infrared MICROSCOPY SYNCHROTRON Radiation 
期刊Polarity-activated super-resolution imaging probe for the formation and morphology of amyloid fibrils
《纳米研究:英文版》2020年第9期2556-2563,共8页Zheng Lv Li Li Zhongwei Man Zhenzhen Xu Hongtu Cui Rui Zhan Qihua He Lemin Zheng Hongbing Fu 
This work was supported by the Ministry of Science and Technology of China(Nos.2017YFA0204503 and 2018YFA0704805);the National Natural Science Foundation of China(Nos.21503139,21573251,21673144,21873065,21833005,81970425 and 21790364);the Beijing Natural Science Foundation of China(No.2192011);the High-level Teachers in Bejing Municipal Universities in the Period of 13^th Five-year Plan(Nos.IDHT20180517 and CIT&TCD20180331);the Open Fund of the State Key Laboratory of Integrated Optoelectronics(No.IOSKL2019KF01);Capacity Building for Sci-Tech Innovation-Fundamental Scientific Research Funds(Nos.025185305000/210,009/19530050162 and 19530012018);Youth Innovative Research Team of Capital Normal University(No,009/19530050148);Beijing Advanced Innovation Center for Imaging Theory and Technology(No.009/19530011009).
The formation of amyloid plaques usually occurs in the early-stage of Alzheimer’s disease(AD).Stimulated emission depletion(STED)imaging provided a powerful tool for visualizing amyloid structures on the nanometer sc...显示全部
关键词:polarity-activated amyloid fibrils super-resolution imaging charge transfer near infrared(NIR)emission 
期刊Effect of metallic nanoparticles on amyloid fibrils and their influence to neural cell toxicity
《纳米研究:英文版》2020年第4期1081-1089,共9页Marianna Barbalinardo Andrea Antosova Marta Gambucci Zuzana Bednarikova Cristiano Albonetti Francesco Valle Paola Sassi Loredana Latterini(ISI) Zuzana Gazova Eva Bystrenova 
This work was partially supported by Slovak grand agency VEGA 2/0145/17,APW-18-0284,Italian flagship NANOMAX,N-CHEM,Ministery o f Education,University and Research(PRIN grant 20173L7W8K).Microscopy was carried out at the SPM@ISMN facility.
The modification of amyloid fibrils cytotoxicity through exogenous nanomaterials is crucial to understand the processes controlling the role of protein aggregation in the related diseases.The influence of nanoparticle...显示全部
关键词:LYSOZYME amyloid fibrils NANOPARTICLES SPECTROSCOPY TOXICITY 
期刊纤维诱导对乳清浓缩蛋白起泡性的改善作用分析被引量:1
《农业机械学报》2018年第8期353-359,共7页徐红华 谭俊艳 谢明明 丁瑞 关琛 王欣 
国家自然科学基金项目(31471682)
纤维诱导对乳清浓缩蛋白(WPC)起泡性具有明显的改善作用。通过向乳清浓缩蛋白中添加一定量成熟的纤维,研究热处理过程中纤维诱导对乳清浓缩蛋白起泡性的影响。结果发现,纤维诱导的乳清浓缩蛋白起泡性远高于乳清浓缩蛋白自发形成纤维的...显示全部
关键词:乳清浓缩蛋白 纤维 起泡性 热处理 
期刊稻秸微/纳米纤丝增强聚丙烯纳米复合材料的研究被引量:3
《林产工业》2009年第2期21-23,33,共4页吴燕 周定国 王思群 张洋 
以稻秸(Oryza sativa L.)纤维纸浆为原料,利用高压超声波震荡使纸浆纤维纤丝化,制得稻秸微/纳米纤丝,并将其作为增强材料填充到聚丙烯基体中制备了稻秸微/纳米纤丝增强聚丙烯纳米复合材料,研究了稻秸微/纳米纤丝以及改性剂(马来酸酐接...显示全部
关键词:纤丝 聚丙烯 纳米复合材料 马来酸酐接枝聚丙烯 拉伸性能 
期刊Amyloid fragments and their toxicity on neural cells
《再生生物材料(英文版)》2019年第2期121-127,共7页Eva Bystrenova Zuzana Bednarikova Marianna Barbalinardo Cristiano Albonetti Francesco Valle Zuzana Gazova 
supported by Slovak grand agency VEGA 2/0145/17,MVTS COST 083/14 action BM1405,SAS-MOST JRP 2015/5 and CNR-SAS bilateral projects CUP B52F15000340005 and CUP B52I12000320005,Italian flagship NANOMAX,N-CHEM。
The formation of amyloid fibrils from soluble proteins is a common form of self-assembly phenomenon that has fundamental connections with biological functions and human diseases.Lysozyme was converted from its soluble...显示全部
关键词:amyloid fibrils protein aggregation neural cells atomic force microscopy fluorescence microscopy 
期刊红景天苷抑制淀粉样β蛋白聚集和降低其细胞毒性的研究
《食品研究与开发》2021年第19期1-7,共7页郝斯佳 韩爱玲 杨亚瑜 方国臻 刘继锋 王硕 
国家自然科学基金(21575102);国家重点研发计划(2020YFF0305002)。
该文利用硫黄素T(thioflavin T,ThT)荧光、刚果红、透射电子显微镜、圆二色谱(circular dichroism,CD)、细胞试验和分子对接等方法,对红景天苷抑制β-淀粉样蛋白40(amyloidβ-peptide 40,Aβ40)的聚集、缓解细胞毒性进行分析。ThT荧光...显示全部
关键词:多酚 红景天苷抑制剂 阿尔兹海默症 纤维 分子对接 
期刊Parkinson’s disease and translational research
《转化神经变性病(英文)》2020年第4期547-557,共11页Elisabeth Dinter Theodora Saridaki Leonie Diederichs Heinz Reichmann Bjorn H.Falkenburger 
by the German Research Foundation(DFG,FA 658/3-1).
Parkinson's disease(PD)is diagnosed when patients exhibit bradykinesia with tremor and/or rigidity,and when these symptoms respond to dopaminergic medications.Yet in the last years there was a greater recognition ...显示全部
关键词:Α-SYNUCLEIN Pre-formed fibrils Protein aggregates AGGRESOME Dopamine deficiency Medium spiny neurons Autophagy 
期刊CaCl_2对纤维核诱导乳清浓缩蛋白聚合能力的影响被引量:1
《农业机械学报》2018年第10期375-380,共6页徐红华 谢明明 丁瑞 马金玉 高子雯 关琛 
国家自然科学基金项目(31471682)
研究了CaCl_2对两种核诱导乳清浓缩蛋白(WPC)在聚合方面的影响。通过向WPC自发、均相核诱导WPC、二次核诱导WPC形成纤维过程中添加CaCl_2,可提高纤维体系的硬度、黏度以及聚合率,并且对核诱导形成的纤维聚合物影响较大。添加CaCl_2后,...显示全部
关键词:乳清浓缩蛋白 纤维 CACL2 均相核 二次核 聚合 
期刊高效制备重组人α-突触核蛋白原纤维方法的建立
《生物学杂志》2020年第2期96-100,共5页罗海玉 吴正存 马开利 
国家自然科学基金(81301073,81571254);国家科技重大专项(2016ZX08011007-003);云南省应用基础项目(2016FA032);中央高校基本科研业务费(2015PT310002、33320140191、3332016116、2016ZX310179-1、2017310040);中国医学科学院医学与健康科技创新工程(2016-I2M-2-001、2016-I2M-1-004);中国医学科学院医学生物学研究所基本科研业务费(IMB2013YB01、2014IMB01ZD)。
通过设计PCR引物,从pcDNA3.1-α-syn载体中扩增人α-突触核蛋白的编码DNA序列,将其克隆至PGEX-5X-1载体中,成功构建了人α-突触核蛋白高效原核表达载体pGEX-5X-1-syn。转化BL21菌株后进行IPTG诱导,通过对诱导剂浓度、诱导时间和温度、...显示全部
关键词:帕金森氏病 Α-突触核蛋白 原纤维 PGEX-5X-1载体 GST 
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