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期刊Binding of rhodopsin and rhodopsin analogues to transducin, rhodopsin kinase and arrestin-1
《世界生物化学杂志:英文版(电子版)》2014年第2期254-268,共15页Nelson A Araujo Carlos E Sanz-Rodríguez José Bubis 
Supported by Grants from FONACIT,Caracas,Venezuela,No.S1-2000000514 and No.LAB-2000001639;and from Decanato de Investigación y Desarrollo,Universidad Simón Bolívar,Caracas,Venezuela,No.S1-IN-CB-001-09
AIM: To investigate the interaction of reconstituted rhodopsin, 9-cis-retinal-rhodopsin and 13-cis-retinal-rhodopsin with transducin, rhodopsin kinase and arrestin-1. METHODS: Rod outer segments(ROS) were isolated fro...显示全部
关键词:RHODOPSIN RHODOPSIN ANALOGUES 9-cis-Retinal 11-cis-Retinal 13-cis-Retinal Photointermediates TRANSDUCIN RHODOPSIN kinase Arrestin-1 Visual process 
期刊Effect of Lithium on Cell Cycle Progression of Pig Airway Epithelial Cells被引量:1
《华中科技大学学报:医学英德文版》2004年第4期318-321,共4页陈文书 吴人亮 王曦 李媛 郝天玲 
ThisprojectwassupportedbyagrantfromNationalNaturalScienceFoundationofChina (No .30 2 0 0 115 )
To investigate the effect of lithium on cell cycle progression of airway epithelial cells, primary pig tracheobronchial epithelial cells were incubated with lithium chloride (LiCl) at different concentrations (0, 5 mm...显示全部
关键词: 细胞周期级数  导气管上皮细胞 糖元合酶激酶3 GLYCOGEN SYNTHASE kinase 3 
期刊Evidence, hypotheses and significance of MAP kinase TNNI3K interacting with its partners
《世界高血压杂志》2012年第2期22-28,共7页Zhong-Fang Lai Yu-Zhen Chen 
TNNI3K is a cardiac-specific and cardiac troponin I(cT n I)-interacting MAP kinase, known to play important roles in promoting cardiac differentiation, maintenance of beating rhythm and contractual force. The molecula...显示全部
关键词:TNNI3K TNNI3 Cardiac-specific MAP kinase Velocity of DIASTOLIC DEPOLARIZATION Phosphorylation of cTnI Antioxidant PROTEIN 1 CALSEQUESTRIN CARDIAC hypertrophy Endothelin-1 CARDIAC myosin binding PROTEIN C 
期刊Functional interactions between steroid hormones and neurotrophin BDNF被引量:1
《世界生物化学杂志:英文版(电子版)》2010年第5期133-143,共11页Tadahiro Numakawa Daisaku Yokomaku Misty Richards Hiroaki Hori Naoki Adachi Hiroshi Kunugi 
Supported by Research Grants for Nervous and Mental Disorders from the Ministry of Health,Labor and Welfare; Health and Labor Sciences Research Grants (Research on Psychiatric and Neurological Diseases and Mental Health);Health and Labor Sciences Research Grants,a grant from the Japan Foundation for Neuroscience and Mental Health;the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (Kunugi H);a Grant-in-Aid for Young Scientists (A) (21680034) from the Ministry of Education,Culture,Sports,Science,and Technology of Japan (Numakawa T)
Brain-derived neurotrophic factor(BDNF),a critical neurotrophin,regulates many neuronal aspects including cell differentiation,cell survival,neurotransmission,and synaptic plasticity in the central nervous system(CNS)...显示全部
关键词:BRAIN-DERIVED neurotrophic factor Steroid hormones NEUROTROPHIN Glucocorticoid Estrogen Tropomyosin-related kinase Extracellular SIGNAL-REGULATED protein kinase Phospholipase  PHOSPHOINOSITIDE 3-kinase 
期刊Molecularly targeted therapies for advanced or metastatic non-small-cell lung carcinoma
《世界临床肿瘤学杂志:英文版》2013年第2期29-42,共14页Soley Bayraktar Caio M Rocha-Lima 
Non-small-cell lung cancer(NSCLC)remains the leading cause of cancer-related death in both men and women in the United States.Platinum-based doublet chemotherapy has been a standard for patients with advanced stage di...显示全部
关键词:NON-SMALL cell lung cancer Molecular targeted therapy Vascular endothelial GROWTH FACTOR Epidermal GROWTH FACTOR receptor TYROSINE kinase inhibitors BRAF ANAPLASTIC lymphoma kinase 
期刊Sphingosine kinase 1 knockout alleviates hepatic ischemia/reperfusion injury by attenuating inflammation and oxidative stress in mice
《国际肝胆胰疾病杂志:英文版》2019年第3期255-265,共11页Guang-Hui Qiang Zhong-Xia Wang An-Lai Ji Jun-Yi Wu Yin Cao Guang Zhang Yi-Yang Zhang Chun-Ping Jiang 
supported by grants from the National Natural Science Foundation of China(81572393 and 81602093);the Natural Science Foundation of Jiangsu Province(BK20160118);the Key Projects supported by Medical Science and Technology Develop-ment Foundation,Nanjing Municipality Health Bureau(ZKX15020 and ZKX17022);Fundamental Research Funds for the Central Universities(021414380215,020414380080 and 021414380329)
Background: Hepatic ischemia/reperfusion(I/R) injury remains a significant problem in clinical practice. Sphingosine kinase 1(Sph K1) phosphorylates sphingosine to sphingosine-1-phosphate(S1 P) which participates in m...显示全部
关键词:ISCHEMIA/REPERFUSION injury SPHINGOSINE kinase 1 INFLAMMATION Oxidative stress 
期刊Ethanolic extract of Azadirachta indica ameliorates ovarian defects through phosphoinositide-3 kinase inhibition in a rat model of polycystic ovary syndrome
《亚太生殖杂志:英文版》2021年第1期21-28,共8页Shraddha V.Patel Harsh Maru Vishal K.Chavda Jigar N.Shah Snehal S.Patel 
Institute of Pharmacy,Nirma University in the form of postgraduate contingency.
Objective:To assess the therapeutic potential of ethanolic extract of Azadirachta(A.)indica in rats with polycystic ovary syndrome(PCOS).Methods:Thirty-five prepubertal female Sprague Dawley rats were randomly divided...显示全部
关键词:Azadirachta indica PI3 kinase QUERCETIN Steroidogenesis Testosterone propionate Wartmannin 
期刊Cloning, tissue expression pattern, and cnromosome localization of human protein kinase By gene
《科学通报:英文版》2000年第20期1832-1839,共8页LAN Fei, YU Long, HU Peirong, MAO Daqin, LI Xiaoquan, ZHANG Min, HUANG Hai & ZHAO ShouyuanStake Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433,ChinaCorrespondence should be addressed to Yu Long 
Protein kinase B (PKB) is a member of the second messenger-regulated subfamily of protein kinases, and plays a key role in cell-cycle regulation, glucose uptake and promotion of cell differentiation. Evidence shows th...显示全部
关键词:HUMAN protein kinase Bγgene cDNA CLONING tissue expression PATTERN HUMAN CHROMOSOME 1q43. 
期刊Spinal CCL2 Promotes Pain Sensitization by Rapid Enhancement of NMDA-Induced Currents Through the ERK-GluN2B Pathway in Mouse Lamina Ⅱ Neurons
《神经科学通报:英文版》2020年第11期1344-1354,共11页Hui Zhang Sui-Bin Ma Yong-Jing Gao Jun-Ling Xing Hang Xian Zhen-Zhen Li Shu-Ning Shen Sheng-Xi Wu Ceng Luo Rou-Gang Xie 
grants from the National Natural Science Foundation of China(81870867,31671088,31471059,and 81502102);the Natural Science Foundation of Shaanxi Province,China(2019SF-071 and 2017ZDJC-01)。
Previous studies have shown that CCL2(C-C motif chemokine ligand 2)induces chronic pain,but the exact mechanisms are still unknown.Here,we established models to explore the potential mechanisms.Behavioral experiments ...显示全部
关键词:C-C motif chemokine ligand 2 Monocyte chemoattractant protein 1 Neuron-glial interaction Extracellular signal-regulated kinase 
期刊Overexpression of <i>OsMAPK2</i>Enhances Low Phosphate Tolerance in Rice and <i>Arabidopsis thaliana</i>
《美国植物学期刊(英文)》2014年第4期452-462,共11页Yeon Jae Hur Doh Hoon Kim 
The mitogen-activated protein kinase (MAPK) cascade is the most important mechanism in environmental responses and developmental processes in plants. The OsMAPK2 gene has been found to function in plant tolerance to d...显示全部
关键词:RICE (Oryza sativa) Phosphorylation MAP kinase Phosphate Homeostasis 
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