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期刊Consequential apoptosis in the cerebellum following injury to the developing rat forebrain.
《Brain Pathology》Taylor DL;Joashi UC;Sarraf C;Edwards AD;Mehmet H
In focal brain lesions, alterations in blood flow and cerebral metabolism can be detected in brain areas remote from the primary injury. The cellular consequences of this phenomenon, originally termed diaschisis, are ...显示全部
关键词:Animals Apoptosis Blotting  Western Cerebellum Hypoxia-Ischemia  Brain In Situ Hybridization microscopy  Electron  Transmission Neurons Poly(ADP-ribose) Polymerases Prosencephalon Rats Rats  Wistar Research Support  Non-U.S. Gov't 
期刊Routine histologic examination of 728 mastectomy scars: did it benefit our patients?
《Plastic and Reconstructive Surgery》Woerdeman LA;Kortmann JB;Hage JJ
BACKGROUND: Routine histologic examination of secondarily excised mastectomy scars is considered good practice, even though the microscopic detection of a metastasis in clinically unsuspected mastectomy scars is rare....显示全部
关键词:Mastectomy  Modified Radical Mastectomy  Segmental Adult Aged Breast Neoplasms Breast Neoplasms  Male Cicatrix Female Humans Male microscopy Middle Aged Neoplasm Recurrence  Local Primary Prevention Risk Factors Time Factors 
期刊A study of retinal penetration of intravitreal tenecteplase in pigs.
《Investigative Ophthalmology & Visual Science》Kwan AS;Vijayasekaran S;McAllister IL;Yu PK;Yu DY
PURPOSE: To determine the degree of retinal penetration of intravitreal tenecteplase in a porcine model. METHODS: Fluorescence-tagged tenecteplase (50 microg in 0.1 mL physiologic saline) was injected into the vitreou...显示全部
关键词:Animals Biological Transport  Active Blood-Retinal Barrier Fibrinolytic Agents Fluorescent Dyes Injections microscopy  Fluorescence Models  Animal Research Support  Non-U.S. Gov't Retina Retinal Hemorrhage Swine Tissue Plasminogen Activator Vitreous Body 
期刊MRT letter: high speed scanning has the potential to increase fluorescence yield and to reduce photobleaching.
microscopy Research and Technique》Borlinghaus RT
True confocal microscopy requires point-shaped illumination and detection. To generate an image, a diffraction limited spot is moved over the sample. Single spot scanning has suffered in the past from low image rates;...显示全部
关键词:Photobleaching Fluorescence Fluorescence Recovery After Photobleaching microscopy  Confocal Models  Theoretical Sensitivity and Specificity 
期刊Dendritic cells as potential adjuvant for immunotherapy in adrenocortical carcinoma.
《Clinical Endocrinology》Papewalis C;Fassnacht M;Willenberg HS;Domberg J;Fenk R;Rohr UP;Schinner S;Bornstein SR;Scherbaum WA;Schott M
OBJECTIVE: Adrenocortical carcinoma (ACC) is a rare malignancy associated with a dismal prognosis. Dendritic cells (DCs) are professional antigen-presenting cells leading to an antitumour immune response. The aim of t...显示全部
关键词:Adjuvants  Immunologic Adrenal Cortex Neoplasms Adrenocortical Carcinoma Adult Antigens  Neoplasm Antineoplastic Agents Cancer Vaccines Dendritic Cells Fatal Outcome Flow Cytometry Humans Hybridomas Hypersensitivity  Delayed Injections Male microscopy  Electron Middle Aged Mitotane Treatment Failure 
期刊RNA interference-mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoral effects in glioblastoma xenografts.
《Human Gene Therapy》Grzelinski M;Urban Klein B;Martens T;Lamszus K;Bakowsky U;Hobel S;Czubayko F;Aigner A
RNA interference (RNAi) is a powerful strategy to inhibit gene expression through specific mRNA degradation mediated by small interfering RNAs (siRNAs). In vivo, however, the application of siRNAs is severely limited ...显示全部
关键词:RNA Interference Animals Brain Neoplasms Carrier Proteins Cytokines Gene Therapy Glioblastoma Mice Mice  Inbred Strains microscopy  Atomic Force Neoplasm Transplantation Polyethyleneimine RNA  Small Interfering Research Support  Non-U.S. Gov't Xenograft Model Antitumor Assays 
期刊Changes in vesicle morphology induced by lateral phase separation modulate phospholipase A2 activity.
《Biochemistry》Burack WR;Dibble AR;Allietta MM;Biltonen RL
The action of phospholipase A2 (PLA2) toward zwitterionic bilayers is modulated by lateral phase separation of reaction products and substrate. The experiments here address the mechanism of this modulation. PLA2 is pa...显示全部
关键词:Kinetics Light Lipid Bilayers Liposomes Magnetic Resonance Spectroscopy Micelles microscopy  Electron Particle Size Phospholipases A Phospholipids Research Support  U.S. Gov't  Non-P.H.S. Research Support  U.S. Gov't  P.H.S. Scattering  Radiation Spectrophotometry 
期刊Cryopreservation of rabbit corneas in dimethyl sulfoxide.
《Investigative Ophthalmology & Visual Science》Wusteman MC;Boylan S;Pegg DE
PURPOSE: To minimize the injury to endothelial cells during cryopreservation of rabbit corneas with dimethyl sulfoxide. METHODS: Rabbit corneas were cryopreserved using 20% wt/wt dimethyl sulfoxide (Me2SO), added and ...显示全部
关键词:Cornea Animals Cell Survival Cold Corneal Stroma Cryopreservation Cryoprotective Agents Dimethyl Sulfoxide Endothelium  Corneal Male microscopy  Confocal Organ Preservation Rabbits Research Support  Non-U.S. Gov't 
期刊Spatial distribution of cytoskeleton intermediate filaments during fetal rat hepatocyte differentiation.
microscopy Research and Technique》Vassy J;Irinopoulou T;Beil M;Rigaut JP
The construction of the liver parenchyma throughout fetal development depends on the elaboration of intercellular contacts between epithelial cells and between epithelial and mesenchymal cells. During this time, the s...显示全部
关键词:Animals Bile Canaliculi development Cell Differentiation Cell Membrane Desmin Intermediate Filaments Keratin Liver microscopy  Confocal Rats Research Support  Non-U.S. Gov't 
期刊Cytoskeletal changes in the brains of mice lacking calcineurin A alpha.
《Journal of Neurochemistry》Kayyali US;Zhang W;Yee AG;Seidman JG;Potter H
Hyperphosphorylated tau, the major component of the paired helical filaments of Alzheimer's disease, was found to accumulate in the brains of mice in which the calcineurin A alpha gene was disrupted [calcineurin A...显示全部
关键词:Animals Antibody Specificity Brain Chemistry Calcineurin Calmodulin-Binding Proteins Cytoskeleton Hippocampus Immunoblotting Immunohistochemistry Mice Mice  Knockout microscopy  Electron Microtubules Mutagenesis Neurofilament Proteins Neurons Phosphoprotein Phosphatase Phosphorylation Research Support  Non-U.S. Gov't Research Support  U.S. Gov't  P.H.S. tau Proteins 
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