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期刊Overexpression of G protein-coupled receptor 31 as a poor prognosticator in human colorectal cancer
《世界胃肠病学杂志:英文版》2018年第41期4679-4690,共12页Yu-Ming Rong Xiao-Ming Huang De-Jun Fan Xu-Tao Lin Feng Zhang Jian-Cong Hu Ying-Xin Tan Xi Chen Yi-Feng Zou Ping Lan 
Supported by National Key Clinical Discipline;and the Medical Scientific Research Foundation of Guangdong Province,No.A2016198;the Science and Technology Planning Project of Guangdong Province,No.20160916,No.2015B020229001 and No.2014SC111
AIM To investigate the expression of G protein-coupled receptor 31 (GPR31) and its clinical significance in human colorectal cancer (CRC).METHODS To determine the association between the GPR31 expression and the progn...显示全部
关键词:G protein-coupled receptor 31 COLORECTAL cancer PREDICTIVE factor METASTASIS Clinical significance 
期刊Bile acid receptors and nonalcoholic fatty liver disease被引量:3
《世界肝病学杂志:英文版(电子版)》2015年第28期2811-2818,共8页Liyun Yuan Kiran Bambha 
With the high prevalence of obesity, diabetes, and otherfeatures of the metabolic syndrome in United States, nonalcoholic fatty liver disease(NAFLD) has inevitably become a very prevalent chronic liver disease and is ...显示全部
关键词:BILE acids BILE acid RECEPTORS Nonalcoholicsteatohepatitis Farnesoid X RECEPTOR TransmembraneG protein-coupled RECEPTOR 5 NONALCOHOLIC fatty liverdisease Hepatic STEATOSIS 
期刊奶山羊短链脂肪酸受体基因(GPR43)编码区(CDS)的克隆及表达分析被引量:3
《农业生物技术学报》2014年第7期876-882,共7页孙雨婷 罗军 邱思源 田慧彬 
转基因生物新品种培育项目(No.2009ZX08009-162B);陕西省重大科技创新项目(No.2009ZKC07-01-1);公益性行业(农业)科研专项(No.201103038)
GPR43是G蛋白偶联受体(G protein-coupled receptors,GPCRs)家族成员之一,在脂代谢中具有潜在的调控作用。本实验旨在克隆奶山羊(Capra hircus)短链脂肪酸受体基因GPR43编码区(coding sequence,CDS)并分析其组织表达谱。根据GenBank上...显示全部
关键词:奶山羊 G protein-coupled receptor 43(GPR43) 克隆 表达分析 
期刊Arrestin-mediated signaling: Is there a controversy?
《世界生物化学杂志:英文版(电子版)》2018年第3期25-35,共11页Vsevolod V Gurevich Eugenia V Gurevich 
Supported by National Institutes of Health RO1 grants,No.EY011500;National Institutes of Health R35 grants,No.GM122491;Cornelius Vanderbilt Endowed Chair(Vanderbilt University),No.NS065868(to Gurevich VV)and No.DA030103(to Gurevich EV)
The activation of the mitogen-activated protein(MAP) kinases extracellular signal-regulated kinase(ERK)1/2 was traditionally used as a readout of signaling of G protein-coupled receptors(GPCRs) via arrestins, as oppos...显示全部
关键词:G protein-coupled receptors ARRESTIN G protein SIGNALING Extracellular SIGNAL-REGULATED KINASE 1/2 c-Jun N-TERMINAL KINASE 3 
期刊Regulatory effects of GRK2 on GPCRs and possible use as a drug target
《中国药理学与毒理学杂志》2017年第10期959-960,共2页Chen-chen HAN Yang MA Yi-fan LI Yang WANG Wei WEI 
supported by National Natural Science Foundation of China(81502123;81330081);Natural Science Foundation of Anhui Province(1308085QH130);Provincial Natural Science Research Foundation of Anhui Province(KJ2014A119)
G protein-coupled receptor kinase 2(GRK2),as a key Ser/Thr protein kinase,belong to the member of the G protein-coupled receptor kinase(GRK)family.The C-terminus of GRK2 including a plekstrin homology domain and the N...显示全部
关键词:G protein-coupled receptor kinase 2 G protein-coupled receptor signal transduction drug targets DISEASE 
期刊Takeda G protein-coupled receptor 5 modu⁃lates depression-like behaviors via hippocam⁃pal CA3 pyramidal neurons afferent to dorso⁃lateral septum
《中国药理学与毒理学杂志》2021年第9期689-690,共2页WANG Hao TAN Yuan-zhi MU Rong-hao TANG Su-su LIU Xiao XING Shu-yun LONG Yan YUAN Dan-hua HONG Hao 
OBJECTIVE Takeda G protein-coupled receptor 5(TGR5)is recognized as a promising target for type 2 diabetes and metabolic syndrome;its expression has been demonstrat⁃ed in the brain and is thought to be neuroprotec⁃tiv...显示全部
关键词:DEPRESSION dorsolateral septum GABAergic neuron HIPPOCAMPUS pyramidal neuron takeda G protein-coupled receptor 5 
期刊CARMA3: A novel scaffold protein in regulation of NF-κB activation and diseases
《世界生物化学杂志:英文版(电子版)》2010年第12期353-361,共9页Jiyuan Sun, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, TX 77030, United States 
Supported by The National Institutes of Health through MD Anderson's Cancer Center Support Grant, No. CA016672
CARD recruited membrane associated protein 3 (CARMA3) is a novel scaffold protein. It belongs to the CARMA protein family, and is known to activate nuclear factor (NF)- κB. However, it is still unknown which receptor...显示全部
关键词:G protein-coupled receptor Β-ARRESTIN CARD recruited membrane associated protein 3 Nuclear factor-κB Cancer ATHEROGENESIS 
期刊Bile acid receptors and gastrointestinal functions
《肝脏研究(英文)》2019年第1期31-39,共9页Alexander L.Ticho Pooja Malhotra Pradeep K.Dudeja Ravinder K.Gill Waddah A.Alrefai 
The work in the authors'laboratories was supported by merit review grants from the Department of Veterans Affairs,United States(VA):BX000152(W.A.Alrefai)and BX002011(P.K.Dudeja);F30 grant DK117535(A.L.Ticho);and R01 grants:DK109709(W.A.Alrefai),DK54016(P.K.Dudeja),DK81858(P.K.Dudeja),DK92441(P.K.Dudeja),DK98170(R.K.Gill),from the USA National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health,United States.
Bile acids modulate several gastrointestinal(GI)functions including electrolyte secretion and absorption,gastric emptying,and small intestinal and colonic motility.High concentrations of bile acids lead to diarrhea an...显示全部
关键词:Bile acids Nuclear receptors Farnesoid X receptor(FXR) Takeda G protein-coupled receptor 5(TGR5) Gastrointestinal function 
期刊New aspects of the C5a receptor
《生命科学与技术进展(英文)》2014年第1期54-63,共10页Hiroshi Nishiura Kiyoshi Ohura 
The process of apoptotic cell death for maintenance of cell homeostasis is now believed to be flexible. To examine the mechanism for this flexibility, the process of programmed cell death is sometimes divided into thr...显示全部
关键词:Adhesion Apoptosis C5a RECEPTOR Differentiation G protein-coupled RECEPTOR NEUTROPHILS PERIODONTITIS RIBOSOMAL protein S19 
期刊基于组织和细胞G蛋白偶联受体表达的新治疗靶标的鉴定(英文)
《中国药理学与毒理学杂志》2017年第10期942-942,共1页Paul A INSEL 
supported by NIH grants(R21CA202608,R21AG053568);Dept of Defense Grant(W81XWH-14-1-0372);Bristol Myers Squibb,Padres Pedal the Cause PTC2017;an ASPET-David Lehr Research Award
G protein-coupled receptors(GPCRs)are the most widely targeted class for approved drugs but only a small portion(-15%)of GPCRs are currently targeted.Work in my laboratory has tested the hypothesis that individual cel...显示全部
关键词:GPCRomics pancreatic ductal adenocarcinoma G protein-coupled receptors 
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