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期刊Modulation of Oxidative Stress Responses by Vitamin E, or Vitamin A plus Vitamin C Treatment in Human retinal Pigment Epithelial Cells
《自然科学期刊(英文)》2015年第12期558-570,共13页Jinggang Yin Christina S. Winborn Fridtjof Thomas Quynh T. Tran John C. Lang Edward Chaum 
The purpose of this study was to characterize the potential of vitamins to protect the retinal pig-ment epithelium (RPE) from oxidative stress (OS). We have previously shown that OS induces the expression of AP1 trans...显示全部
关键词:Vitamin Supplementation AP1 Transcription Factors Oxidative Stress retinal PIGMENT EPITHELIUM AGE-RELATED MACULAR DEGENERATION 
期刊Peripapillary subretinal neovascularization in retinoblastoma
《Graefe's Archive for Clinical and Experimental Ophthalmology》Satoru Kase[1,2]; Jignesh G. Parikh[1,2];Narsing A. Rao[1,2]
Background Peripapillary subretinal neovascularization (PSRNV) is a rare type of choroidal neovascularization. Herein we report a case of retinoblastoma complicating PSRNV, and discuss the histopathological findings....显示全部
关键词:Peripapillary subretinal neovascularizarion retinoblastoma retinal pigment epithelial cells Histopathology 
期刊外源性脯氨酸羟化酶对人RPE细胞中缺氧诱导因子通路的负向调节作用被引量:2
《中华实验眼科杂志》2016年第3期234-238,共5页马昱 唐少华 姜燕荣 石璇 
背景目前抗VEGF药物的应用已广泛用于眼部新生血管性疾病发病的治疗,但有部分患者的疗效并不理想,因此研究VEGF的上游基因缺氧诱导因子-1(HIF—1)及其限速酶脯氨酸羟化酶(PHDs)在新生血管形成中的作用具有重要的临床意义。目的探...显示全部
关键词:细胞缺氧 血管内皮生长因子 基因表达调控 缺氧诱导因子-1 脯氨酸羟化酶/代谢  转录因子 视网膜色素上皮细胞 
期刊Blue light-triggered photochemistry and cytotoxicity of retinal
《Cellular Signalling》Kasun Ratnayake[a]; John L. Payton[b]; Mitchell E. Meger[a]; Nipunika H. Godage[a]; Emanuela Gionfriddo[a]; Ajith Karunarathne[a]
The chemical- and photo- toxicity of chromophore retinal on cells have long been debated. Although we recently showed that retinal and blue light exposure interrupt cellular signaling, a comprehensive study examining ...显示全部
关键词:retinal  Blue light  Reactive oxygen species  Singlet oxygen  Rose bengal  Lipid peroxidation  G proteins  Ras  Signal transduction  PIP2  Farnesyl  Geranylgeranyl 
期刊Protection of tight junction between RPE cells with tissue factor targeting peptide
《国际眼科杂志:英文版》2018年第10期1594-1599,共6页Xiu-Lan Zou Guan-Feng Wang Dan-Dan Li Jing-Xia Chen Chun-Li Zhang Yong-Zhen Yu Wen-Jie Zhou Yu-Ping Zou Ben-Qiang Rao 
Supported by Science and Technology Project of Guangzhou City(No.2014J4100035);the Project of the Third Affiliated Hospital of Guangzhou Medical University(No.2013Y06)
AIM:To investigate the effect of tissue factor targeting peptide(TF-TP)on retinal pigment epithelium(RPE)cells tight junctions.METHODS:Cell counting kit-8(CCK-8)was used to measure the proliferation of ARPE-19 cells.E...显示全部
关键词:tissue factor TARGETING PEPTIDE lipopolysaccharide tight junction ZO-1 retinal PIGMENT EPITHELIUM 
期刊Role of Smad4 from ocular surface ectoderm in retinal vasculature development
《国际眼科杂志:英文版》2020年第2期231-238,共8页Jing Li Jin-Song Zhang Jiang-Yue Zhao Guo-Ge Han 
Supported by Tianjin Natural Science Funds(No.18JCQNJC10600).
●AIM:To investigate how signals from lens regulate retinal vascular development and neovascularization.●METHODS:Le-Cre transgenic mouse line was employed to inactivate Smad4 in the surface ectoderm selectively.Stand...显示全部
关键词:SMAD4 retinal VASCULATURE SURFACE ECTODERM 
期刊Alterations in the polysialylated neural cell adhesion molecule and retinal ganglion cell density in mice with diabetic retinopathy
《国际眼科杂志:英文版》2018年第10期1608-1615,共8页Natalia Lobanovskaya Monika Jürgenson Anu Aonurm-Helm Alexander Zharkovsky 
Supported by the Estonian Science Council Grant(Institutional research founding)IUT2-3
AIM:To investigate the impact of polysialylated neural cell adhesion molecule(PSA-NCAM)on the survival of retinal ganglion cells(RGCs)in the experimentally induced diabetes in mice.METHODS:Diabetes was induced in 2.5 ...显示全部
关键词:DIABETIC retinOPATHY matrix metalloproteinase-9 polysialylated neural cell adhesion MOLECULE retinal GANGLION cells 
期刊超广角眼底成像与全视网膜镜在周边部视网膜病变的检查效果比较
《中华眼外伤职业眼病杂志》2021年第2期91-95,共5页万晶晶 陈悦 陈晓君 
目的比较应用超广角眼底成像系统与全视网膜镜周边部视网膜病变的检查效果。方法前瞻性病例对照研究。对郑州大学第一附属医院门诊2019年7月至2019年12月以眼前黑影飘动为主诉者1200例(2400只眼),分别应用自然瞳孔下超广角眼底成像系统...显示全部
关键词:眼底 视网膜 全视网膜镜 系统 眼底成像 超广角 病变 视网膜 周边部 比较 效果 
期刊Novel transscleral sutureless subretinal fluid drainage using a 25-gauge trocar-cannula with a self-closing valve in patients with advanced Coats disease
《国际眼科杂志:英文版》2019年第9期1444-1449,共6页Liang Li Song-Feng Li Jing-Hua Liu Guang-Da Deng Yan Ma Jing Ma Hai Lu 
Supported by Beijing Tongren Hospital,Capital Medical University(No.TRZDYXZY201703)
AIM: To assess surgical outcomes of a novel method of transscleral drainage of subretinal fluid using a 25-gauge trocar-cannula with a self-closing valve(DTV) in patients with severe exudative retinal detachment(ERD) ...显示全部
关键词:Coats disease subretinal fluid EXUDATIVE retinal DETACHMENT transscleral drainage 
期刊A new component in the a-wave of the human cone electroretinogram
《Documenta Ophthalmologica》Peter Gouras, Cynthia MacKay
The human cone electroretinogram (ERG) to a full field flash has been examined on a rod saturating background (17,000 photopic trolands). With strong stimuli, a negative wavelet appears in the falling phase of the a-w...显示全部
关键词:electroretinogram  cones  second order retinal neurons  
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